| 產(chǎn)品編號(hào) | bs-1088R-BF488 |
| 英文名稱 | Rabbit Anti-T Beta 10/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的胸腺素β10抗體 |
| 別 名 | MIG 12; MIG12; Migration inducing gene 12; Migration inducing protein 12; Ptmb10; TB 10; TB10; Thyb 10; Thyb10; Thymosin beta-10; Thymosin beta 10; TMSB10; TYB10_HUMAN |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 生長(zhǎng)因子和激素 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 4.9kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human T Beta 10 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The beta thymosins are a family of related peptides, initially isolated from calf thymus but known to be present in a wide variety of mammalian and other vertebrate cells and tissues. Thymosin beta 4 was the first member of the family to be characterized. Although TMSB4 was initially proposed to be a thymic hormone acting at early stages of T cell maturation, the high concentration of the protein and its mRNA in a number of other tissues and cells, as well as the lack of an identifiable secretory signal sequence, suggested that it had a general function in many cell types. Thymosin beta 10 is closely related in sequence to TMSB4 and is also an actin sequestering protein. Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Subcellular Location: Cytoplasm, cytoskeleton. Similarity: Belongs to the thymosin beta family. Database links: Entrez Gene: 9168 Human Omim: 188399 Human SwissProt: P63313 Human SwissProt: Q596K9 Human Unigene: 446574 Human Unigene: 5983 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胸腺素β10同其他胸腺素一樣也是多肽類激素，具有增強(qiáng)細(xì)胞免疫功能和調(diào)節(jié)免疫平衡等作用，胸腺素可使由骨髓產(chǎn)生的干細(xì)胞轉(zhuǎn)變?yōu)門淋巴細(xì)胞，因而可增強(qiáng)細(xì)胞免疫功能，對(duì)體液免疫的影響甚微。 近年來(lái)研究認(rèn)為：該蛋白于腫瘤轉(zhuǎn)移有關(guān)，胸腺素β10在腫瘤轉(zhuǎn)移潛能的增高伴有肌動(dòng)蛋白多聚體的丟失和微絲結(jié)構(gòu)的解聚,微絲骨架的這種變化與Tβ10的表達(dá)增高具有相關(guān)性。 |
