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Rabbit Anti-T Beta 10/PE-Cy3 Conjugated antibody (bs-1088R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@www.eweiwc.cn
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1088R-PE-Cy3
英文名稱 Rabbit Anti-T Beta 10/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的胸腺素β10抗體
別    名 MIG 12; MIG12; Migration inducing gene 12; Migration inducing protein 12; Ptmb10; TB 10; TB10; Thyb 10; Thyb10; Thymosin beta-10; Thymosin beta 10; TMSB10; TYB10_HUMAN  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 4.9kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human T Beta 10
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The beta thymosins are a family of related peptides, initially isolated from calf thymus but known to be present in a wide variety of mammalian and other vertebrate cells and tissues. Thymosin beta 4 was the first member of the family to be characterized. Although TMSB4 was initially proposed to be a thymic hormone acting at early stages of T cell maturation, the high concentration of the protein and its mRNA in a number of other tissues and cells, as well as the lack of an identifiable secretory signal sequence, suggested that it had a general function in many cell types. Thymosin beta 10 is closely related in sequence to TMSB4 and is also an actin sequestering protein.

Function:
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.

Subcellular Location:
Cytoplasm, cytoskeleton.

Similarity:
Belongs to the thymosin beta family.

Database links:

Entrez Gene: 9168 Human

Entrez Gene: 100364435 Rat

Entrez Gene: 50665 Rat

Omim: 188399 Human

SwissProt: P63313 Human

SwissProt: Q596K9 Human

SwissProt: P63312 Rat

Unigene: 446574 Human

Unigene: 5983 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胸腺素β10同其他胸腺素一樣也是多肽類激素,具有增強細胞免疫功能和調節(jié)免疫平衡等作用,胸腺素可使由骨髓產生的干細胞轉變?yōu)門淋巴細胞,因而可增強細胞免疫功能,對體液免疫的影響甚微。
近年來研究認為:該蛋白于腫瘤轉移有關,胸腺素β10在腫瘤轉移潛能的增高伴有肌動蛋白多聚體的丟失和微絲結構的解聚,微絲骨架的這種變化與Tβ10的表達增高具有相關性。
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