| 產(chǎn)品編號(hào) | bs-1175R-AP |
| 英文名稱 | Rabbit Anti-SHBG/AP Conjugated antibody |
| 中文名稱 | 堿性磷酸酶（AP）標(biāo)記的性激素結(jié)合球蛋白抗體 |
| 別 名 | Sex Hormone Binding Globulin; ABP; Androgen binding protein; MGC126834; MGC138391; SBP; Sex steroid binding protein; SHBG; TEBG; Testis specific androgen binding protein; Testosterone binding beta globulin; Testosterone Estradiol Binding Globulin; Testosterone estrogen binding globulin; SHBG_HUMAN; Sex hormone-binding globulin; Sex steroid-binding protein; Testis-specific androgen-binding protein; Testosterone-estradiol-binding globulin; TeBG; Testosterone-estrogen-binding globulin. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 生長因子和激素 結(jié)合蛋白 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SHBG |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Sex hormone binding globulin (SHBG) is a glycoprotein synthesized by the liver. Circulating androgen and estrogen concentrations influence SHBG synthesis. Elevated testosterone, for example, causes SHBG synthesis to decrease, whereas high estrogen stimulates SHBG production. The regulation of SHBG synthesis, combined with SHBG's higher affinity for testosterone, impacts bioavailable testosterone levels. SHBG binds up to 98 percent of the steroid hormones in the blood including 5a-dihydrotestosterone (DHT), testosterone and androstenediol with particularly high affinity, and estradiol and estrone with slightly lower affinity. Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. Subunit: Homodimer. Subcellular Location: Secreted . Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. Tissue Specificity: Isoform 1 and isoform 2 are present in liver and testis. Post-translational modifications: Variant Asn-356 contains one N-linked (GlcNAc...) at position 356. Similarity: Contains 2 laminin G-like domains. Database links: Entrez Gene: 6462 Human Omim: 182205 Human SwissProt: P04278 Human Unigene: 632235 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 性激素結(jié)合球蛋白(SHBG),又稱睪酮—雌二醇結(jié)合球蛋白。 SHBG是一運(yùn)輸性激素的載體，它在性激素人作用過程中以及在各種生理病理情況下都有一定的變化和意義。 SHBG是由母體肝臟產(chǎn)生的循環(huán)類固醇類結(jié)合球蛋白，執(zhí)行載體蛋白的功能，胰島素是肝臟合成SHBG的強(qiáng)大的抑制因子，胰島素抑制效應(yīng)的主要作用點(diǎn)在于競爭性刺激肝臟SHBG的產(chǎn)生，因而SHBG減少是高胰島素血癥、胰島素抵抗的標(biāo)志。 |
