99精品欧美一区二区三区综合在线,国产精品一区二区的,欧美亚洲国产日韩综合,99精品视频在线观看2

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
99热久久资源中文字幕,欧美大片免费影院在线观看,在线播放亚洲欧洲日韩
Rabbit Anti-TRP12/TRPV4/Biotin Conjugated antibody (bs-6425R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@www.eweiwc.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@www.eweiwc.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-6425R-Bio
英文名稱 Rabbit Anti-TRP12/TRPV4/Biotin Conjugated antibody
中文名稱 生物素標(biāo)記的瞬時(shí)受體電位蛋白12抗體
別    名 osm-9-like TRP channel 4; OTRPC 4; OTRPC4; Transient receptor potential cation channel subfamily V member 4; Transient receptor potential protein 12; TRP 12; TRP12; TRPV 4; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; Vanilloid receptor-related osmotically-activated channel; VR 4; VR OAC; VR4; VRL 2; VRL2; VROAC.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  微生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  通道蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 96kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TRPV4
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The detection of noxious stimuli (chemical, mechanical, or thermal) occurs predominantly at the peripheral terminals of primary afferent neurons. This information is ultimately transmitted to the central nervous system to evoke appropriate protective reflexes. TRPV4 is a non selective calcium permeant, swell activated, cation channel probably involved in osmotic and mechano sensitivity. Activation by exposure to hypotonicity within the physiological range, low pH, citrate and phorbol esters exhibits an outward rectification. Once activated the channel seems to be regulated in a calmodulin dependent manner, with a negative feedback mechanism.

Function:
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.

Subunit:
Homotetramer (Probable). Self-associates in a isoform-specific manner. Isoforms 1/A and 5/D but not isoform 2/B, 4/C and 6/E can oligomerize. Interacts with calmodulin. Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES. Interacts with CTNNB1. The TRPV4 and CTNNB1 complex can interact with CDH1. Part of a complex containing MLC1, AQP4, HEPACAM and ATP1B1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. Isoform 1: Cell membrane. Isoform 5: Cell membrane.

Tissue Specificity:
Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level).

Post-translational modifications:
Phosphorylation results in enhancement of its channel function.

DISEASE:
Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3) [MIM:113500]; also known as brachyrachia. The brachyolmias constitute a clinically and genetically heterogeneous group of skeletal dysplasias characterized by a short trunk, scoliosis and mild short stature. BRAC3 is an autosomal dominant form with severe kyphoscoliosis and flattened, irregular cervical vertebrae.
Defects in TRPV4 are the cause of spondylometaphyseal dysplasia Kozlowski type (SMDK) [MIM:184252]. The spondylometaphyseal dysplasias (SMDs) are a group of short-stature disorders distinguished by abnormalities in the vertebrae and the metaphyses of the tubular bones. SMDK is an autosomal dominant disorder characterized by significant scoliosis and mild metaphyseal abnormalities in the pelvis. The vertebrae exhibit platyspondyly and overfaced pedicles.

Similarity:
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily.
Contains 3 ANK repeats.

Database links:

Entrez Gene: 59341 Human

Entrez Gene: 63873 Mouse

Entrez Gene: 66026 Rat

Omim: 605427 Human

SwissProt: Q9HBA0 Human

SwissProt: Q9EPK8 Mouse

SwissProt: Q9ERZ8 Rat

Unigene: 506713 Human

Unigene: 266450 Mouse

Unigene: 64508 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.www.eweiwc.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲精品成a人在线观看| 97人妻精品一区二区三区视频| 一级e片在线观看| 丁香婷婷色婷婷粗大| 男人操女人下面国产剧情| 爆乳喷奶水无码正在播放| 怎么样操女人的逼亚洲Av黄片段| 美女爽的嗷嗷叫免费| 插女人下面高潮视频| 色熟妇人妻久久中文字幕| 国产乱理伦片在线观看夜| 国产一区二区在线观看精品| 黄色高清带三级1集2集| 男人扒开女人腿狂躁免费| 亚洲一区二区三区精品日韩| 美女呻吟翘臀后进爆白浆| 人妻少妇精品视频12p| 欧美国产人妖另类色视频| 久久久久九九九国产精品| 中文字幕亚洲欧美精品一区二区| 亚洲高清中文字幕一区二区三区| 精品无码国产一区二区三区麻豆| 尤物性生活午夜在线视频| 黑人大屌爆操骚货| 澳门一区二区免费下线观看| 操我骚逼抽插视频| 亚洲精品美女久久久| 欧美日韩视频在线一区二区| 国产亚洲精品高清视频免费| 久久精品国产自清天天线| 国产羞羞的视频在线观看| 婷婷激情五月天四房| 免费看看小骚逼逼| 欧美一区二区三区高清性群p| 欧美国产人妖另类色视频| 国产精品免费久久久久久| 激情久久久久久久久久久| 亚洲男人的天堂2023| 国产乱色国产精品免费播放| 国内揄拍国内精品| 欧美大鸡巴操大骚逼|