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RSPO2 Rabbit pAb (bs-18876R)  
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產(chǎn)品編號(hào) bs-18876R
英文名稱(chēng) RSPO2 Rabbit pAb
中文名稱(chēng) RSPO2蛋白抗體
別    名 CRISTIN2; hRspo2; RSPO2_HUMAN; R spondin 2; R spondin 2 homolog; R-spondin 2 homolog(Xenopus laevis); R-spondin family, member 2; Roof plate-specific spondin-2.  
研究領(lǐng)域 細(xì)胞生物  發(fā)育生物學(xué)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
克 隆 號(hào)
交叉反應(yīng) Mouse,Rat (predicted: Human,Pig,Cow,Dog)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 26 kDa
檢測(cè)分子量
細(xì)胞定位 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RSPO2: 22-100/243 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng) This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]

Function:
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.

Subunit:
Interacts with WNT1. Binds heparin By similarity. Interacts with LGR4, LGR5 and LGR6.

Subcellular Location:
Secreted

Similarity:
Belongs to the R-spondin family.
Contains 1 FU (furin-like) repeat.
Contains 1 TSP type-1 domain.

SWISS:
Q6UXX9

Gene ID:
340419

Database links:

Entrez Gene: 340419 Human

Entrez Gene: 239405 Mouse

Entrez Gene: 500863 Rat

Omim: 610575 Human

SwissProt: Q6UXX9 Human

SwissProt: Q8BFU0 Mouse




產(chǎn)品圖片
Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Mouse Large intestine tissue lysates Lane 3: Mouse Placenta tissue lysates Lane 4: Mouse Liver tissue lysates Lane 5: Mouse Lung tissue lysates Lane 6: Rat Cerebrum tissue lysates Lane 7: Rat Large intestine tissue lysates Lane 8: Rat Placenta tissue lysates Lane 9: Rat Liver tissue lysates Lane 10: Rat Lung tissue lysates Primary: Anti-RSPO2 (bs-18876R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 26 kDa Observed band size: 28 kDa
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