| 產(chǎn)品編號 | bs-1849R |
| 英文名稱 | Midkine Rabbit pAb |
| 中文名稱 | 中期因子/肝素結(jié)合生長因子抗體 |
| 別 名 | Amphiregulin associated protein; ARAP; FLJ27379; MDK; Midgestation and kidney protein; MK 1; MK; MK1; NEGF 2; NEGF2; neurite growth promoting factor 2; Neurite outgrowth promoting protein; MK_HUMAN. |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Rat (predicted: Mouse,Cow,Dog,Horse,Fruit Fly) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 13.4 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Midkine: 23-100/140 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Midkine exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Its expression is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines. Function: Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). Subunit: Homodimer. Interacts with ALK. Subcellular Location: Secreted. Similarity: Belongs to the pleiotrophin family. SWISS: P21741 Gene ID: 4192 Database links: Entrez Gene: 4192 Human Entrez Gene: 17242 Mouse Omim: 162096 Human SwissProt: P21741 Human SwissProt: P12025 Mouse Unigene: 21528 Cow Unigene: 82045 Human Unigene: 906 Mouse Unigene: 17447 Rat 中期因子(midkine, MK)具有多種生物學(xué)功能: 可促進神經(jīng)軸突 的生長和各種胚胎神經(jīng)元的存活,做為一種有絲分裂原,與腫瘤的發(fā)生密切相關(guān)，MK還有較強的 促血管生成特性, 經(jīng)研究證實, MK可促進內(nèi)皮細(xì)胞增殖并 提高血管的密度，在多種腫瘤組織和腫 瘤患者的血清中的水平都明顯升高。MK和多向促激素(p leiotro2 phin, PTN)同屬于一類新的結(jié)合肝素的生長因子家 族。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Rat Embryo tissue lysates
Lane 2: Rat Uterus tissue lysates
Primary: Anti-Midkine (bs-1849R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 13.4 kDa
Observed band size: 16 kDa
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