| 產(chǎn)品編號 | bs-1088R |
| 英文名稱 | T Beta 10 Rabbit pAb |
| 中文名稱 | 胸腺素β10抗體 |
| 別 名 | MIG 12; MIG12; Migration inducing gene 12; Migration inducing protein 12; Ptmb10; TB 10; TB10; Thyb 10; Thyb10; Thymosin beta-10; Thymosin beta 10; TMSB10; TYB10_HUMAN |
| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 生長因子和激素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Pig,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 4.9 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human T Beta 10: 13-110/44 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The beta thymosins are a family of related peptides, initially isolated from calf thymus but known to be present in a wide variety of mammalian and other vertebrate cells and tissues. Thymosin beta 4 was the first member of the family to be characterized. Although TMSB4 was initially proposed to be a thymic hormone acting at early stages of T cell maturation, the high concentration of the protein and its mRNA in a number of other tissues and cells, as well as the lack of an identifiable secretory signal sequence, suggested that it had a general function in many cell types. Thymosin beta 10 is closely related in sequence to TMSB4 and is also an actin sequestering protein. Function: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Subcellular Location: Cytoplasm, cytoskeleton. Similarity: Belongs to the thymosin beta family. SWISS: Q596K9 Gene ID: 9168 Database links: Entrez Gene: 9168 Human Omim: 188399 Human SwissProt: P63313 Human SwissProt: Q596K9 Human Unigene: 446574 Human Unigene: 5983 Rat 胸腺素β10同其他胸腺素一樣也是多肽類激素，具有增強(qiáng)細(xì)胞免疫功能和調(diào)節(jié)免疫平衡等作用，胸腺素可使由骨髓產(chǎn)生的干細(xì)胞轉(zhuǎn)變?yōu)門淋巴細(xì)胞，因而可增強(qiáng)細(xì)胞免疫功能，對體液免疫的影響甚微。 近年來研究認(rèn)為：該蛋白于腫瘤轉(zhuǎn)移有關(guān)，胸腺素β10在腫瘤轉(zhuǎn)移潛能的增高伴有肌動蛋白多聚體的丟失和微絲結(jié)構(gòu)的解聚,微絲骨架的這種變化與Tβ10的表達(dá)增高具有相關(guān)性。 |
| 產(chǎn)品圖片 |
Tissue/cell: mouse small intestine; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal go
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