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Rabbit Anti-CD62p  antibody (bs-0561R)  
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產(chǎn)品編號 bs-0561R
英文名稱 Rabbit Anti-CD62p  antibody
中文名稱 P選擇素/白細胞內皮細胞粘附分子3抗體
別    名 P-selectin; CD_antigen: CD62P; CD62 antigen-like family member P; GMP 140; GMP-140; GMRP; Granule membrane protein 140; Granulocyte membrane protein; GRMP; LECAM 3; LECAM3; Leukocyte endothelial cell adhesion molecule 3; Leukocyte-endothelial cell adhesion molecule 3; P Selectin; PADGEM; Platelet activation dependent granule-external membrane protein; PSEL; sp-selectin; LYAM3_HUMAN.  
Specific References  (7)     |     bs-0561R has been referenced in 7 publications.
[IF=25.809] Liu G et al. Engineering Biomimetic Platesomes for pH‐Responsive Drug Delivery and Enhanced Antitumor Activity. Adv Mater. 2019 Jun 20:e1900795.  WB ;  Mouse.  
[IF=16.744] Haifeng Gong. et al. Platelet shipped IL-10 enhances drug delivery for attenuating I/R- or UUO-induced renal injury. CHEM ENG J. 2023 Apr;462:142258  WB ;  Rat.  
[IF=9.473] Stanley M. H. Chan. et al. Inhibition of oxidative stress by apocynin attenuated chronic obstructive pulmonary disease progression and vascular injury by cigarette smoke exposure. BRIT J PHARMACOL. 2023 Mar;:  IHC ;  Mouse.  
[IF=6.419] Qi-Rui Li. et al. Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery. Drug Deliv. 2022;29(1):937-949  IHC ;  Mouse.  
[IF=5.21] Ma, Yanqin, et al. "Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta." Archives of toxicology 86.6 (2012): 849-856.  WB ;  Rabbit.  
[IF=1.38] Hu, Zhibin, et al. "Comparative analysis of preservation method and intermittent perfusion volume on the expression of endothelial and inflammatory markers by coronal artery and myocardium in porcine donor hearts." ASAIO journal (American Society for Artificial Internal Organs: 1992) (2014).  IHC-P ;  Pig.  
[IF=0] Rui-Kai and Jian Effects of xinfeng capsules on expression of platelet granule membrane protein 140 and platelet cluster of differentiation 40 ligand in peripheral blood of adjuvant arthritis rats. (2012) Int.J.Rheumato. 2012:139696  FC/FACS ;  Rat.  
研究領域 心血管  細胞生物  免疫學  干細胞  細胞粘附分子  上皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,Mouse,Rat
產(chǎn)品應用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 88kDa
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse P-selectin: 701-768/768 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]

Function:
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Subunit:
Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

DISEASE:
Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

Similarity:
Belongs to the selectin/LECAM family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 9 Sushi (CCP/SCR) domains.

SWISS:
Q01102

Gene ID:
6403

Database links:

Entrez Gene: 6403 Human

Entrez Gene: 20344 Mouse

Entrez Gene: 25651 Rat

Omim: 173610 Human

SwissProt: P16109 Human

SwissProt: Q01102 Mouse

SwissProt: P98106 Rat

Unigene: 73800 Human



P-選擇素(P—selectin)是細胞黏附分子選擇素家族的主要成員,又稱CD62p,可以介導各種白細胞和腫瘤細胞的粘附。
CD62p又稱GMP—140或PADGEM蛋白(血小板活化依賴α顆粒膜蛋白),它在血小板與單核細胞及中性粒細胞相互作用中起關鍵作用。
產(chǎn)品圖片
25 ug total protein per lane of various lysates (see on figure) probed with CD62p monoclonal antibody, unconjugated (bs-0561R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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