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Cyclooxygenase 2 Rabbit pAb (bs-0732R)

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產品編號	bs-0732R
英文名稱	Cyclooxygenase 2 Rabbit pAb
中文名稱	環(huán)氧合酶2/前列腺素內過氧化物合成酶2抗體
別名	PTGS2; COX 2; COX-2; Cyclooxygenase; Cyclooxygenase2; Cyclooxygenase-2; COX2; hCox 2; PGG/HS; PGH synthase 2; PGHS 2; PGHS2; PHS 2; PHS II; PHS2; Prostaglandin endoperoxide synthase 2; Prostaglandin G/H synthase 2 precursor; Prostaglandin G/H synthase and cyclooxygenase; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; TIS10II; PGH2_HUMAN.
	Specific References (44) \| bs-0732R has been referenced in 44 publications. [IF=18.027] Ke Li. et al. Oxygen Self-Generating Nanoreactor Mediated Ferroptosis Activation and Immunotherapy in Triple-Negative Breast Cancer. ACS NANO. 2023;17(5):4667–4687 WB ; Mouse. PubMed:36861638 [IF=6.6] Ana Paula Girol. et al. Annexin A1 Mimetic Peptide and Piperlongumine: Anti-Inflammatory Profiles in Endotoxin-Induced Uveitis. Cells-Basel. 2021 Nov;10(11):3170 IHC ; Rat. PubMed:34831393 [IF=6.576] Rong Li. et al. Integrated Analysis Reveals the Targets and Mechanisms in Immunosuppressive Effect of Mesalazine on Ulcerative Colitis. FRONT NUTR. 2022; 9: 867692 IHC,IF ; Mouse. PubMed:35662946 [IF=5.988] Jing-Bei Zhang. et al. The combination of Lonicerae Japonicae Flos and Forsythiae Fructus herb-pair alleviated inflammation in liver fibrosis.. FRONT PHARMACOL. 2022 Aug;13:984611-984611 WB ; Rat. PubMed:36059967 [IF=5.201] Zhong Yuyi. et al. MIR143 Inhibits Steroidogenesis and Induces Apoptosis Repressed by H3K27me3 in Granulosa Cells. Front Cell Dev Biol. 2020 Oct;8:1159 WB ; Porcine. PubMed:33195195 [IF=5.151] Zhang L et al. The Protective Activities of Dietary Sea Cucumber Cerebrosides against Atherosclerosis through Regulating Inflammation and Cholesterol Metabolism in Male Mice.Mol Nutr Food Res. 2018 Aug;62(16):e1800315. WB ; Mouse. PubMed:29883529 [IF=4.932] Qingyu Meng. et al. Morin hydrate inhibits atherosclerosis and LPS-induced endothelial cells inflammatory responses by modulating the NFκB signaling-mediated autophagy. Int Immunopharmacol. 2021 Nov;100:108096 WB ; Human. PubMed:34464886 [IF=4.82] Fattori, Victor, et al. "Vinpocetine reduces diclofenac-induced acute kidney injury through inhibition of oxidative stress, apoptosis, cytokine production, and NF-κB activation in mice." Pharmacological Research (2017). IHC-P ; Mouse. PubMed:28315429 [IF=4.096] Xiaojun Pan. et al. Fibroblast growth factor-2?alleviates the capillary leakage and inflammation in sepsis. Mol Med. 2020 Dec;26(1):1-13 WB ; Mouse. PubMed:33187467 [IF=3.998] Ines Fasolino. et al. 2D exfoliated black phosphorus influences healthy and cancer prostate cell behaviors. Sci Rep-Uk. 2021 Mar;11(1):1-13 IF ; Human. PubMed:33712665 [IF=3.998] Naiqiang Zhu. et al. Network pharmacology integrated with experimental validation revealed the anti-inflammatory effects of Andrographis paniculata. Sci Rep-Uk. 2021 May;11(1):1-16 WB ; Mouse. PubMed:33963245 [IF=3.73] Gao, Jin-Hang, et al. "Celecoxib Ameliorates Portal Hypertension of the Cirrhotic Rats through the Dual Inhibitory Effects on the Intrahepatic Fibrosis and Angiogenesis." PLOS ONE 8.7 (2013): e69309. WB ; Rat. PubMed:23922700 [IF=3.69] Yuhua Li. et al. Jiaolong capsule protects SD rats against 2,4,6-trinitrobenzene sulfonic acid induced colitis. J Ethnopharmacol. 2021 Apr;269:113716 WB ; Rat. PubMed:33352238 [IF=3.69] Xiaoyan Xia. et al. Ameliorative effect of white tea from 50-year-old tree of Camellia sinensis L. (Theaceae) on kidney damage in diabetic mice via SIRT1/AMPK pathway. J Ethnopharmacol. 2021 May;272:113919 WB ; Mouse. PubMed:33577915 [IF=3.641] Wenbo Ge. et al. 17β-estradiol protects sheep oviduct epithelial cells against lipopolysaccharide-induced inflammation in vitro. Mol Immunol. 2020 Nov;127:21 WB ; Sheep. PubMed:32905905 [IF=3.457] Zhang J et al. Hydroxysafflor yellow A suppresses angiogenesis of hepatocellular carcinoma through inhibition of p38 MAPK phosphorylation. (2019)Biomedicine & Pharmacotherapy, 109, 806–814. IHC ; Mouse. PubMed:30551534 [IF=3.405] Tianyu Yang. et al. Material properties of degradable alloy Fe–30Mn–0.6N and its effect on ferroptosis in synoviocytes. J BIOMED MATER RES B. 2022 Sep;: WB ; Rabbit. PubMed:36066321 [IF=3.37] Zhang et al. Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. (2014) World.J.Gastroentero. 20:1614-22 IHC-P ; Rat. PubMed:24587639 [IF=3.368] Liu Tang. et al. Topical Application with Conjugated Linoleic Acid Ameliorates 2, 4‐dinitrofluorobenzene‐Induced Atopic Dermatitis‐like Lesions in BALB/c Mice. Exp Dermatol. 2021 Feb;30(2):237-248 WB ; Mouse. PubMed:33206422 [IF=3.25] Li, Wei, et al. "Cyclin d1 expression and the inhibitory effect of celecoxib on ovarian tumor growth in vivo." International journal of molecular sciences 11.10 (2010): 3999-4013. WB ; Human. PubMed:21152316 [IF=3.241] Zhang L et al. Eicosapentaenoic acid in the form of phospholipid exerts superior anti-atherosclerosis effects than its triglyceride form in ApoE-/-mice. Food & Function. 2019 WB ; Mouse. PubMed:31246210 [IF=3.118] Possebon?L et al. Mimetic peptide AC2-26 of annexin A1 as a potential therapeutic agent to treat COPD. Int Immunopharmacol. 2018 Oct;63:270-281. IHC-P ; Rat. PubMed:30121452 [IF=2.96] Xinna Wang. et al. Hejie Zhitong prescription promotes sleep and inhibits nociceptive transmission-associated neurotransmitter activity in a rodent migraine model. Chin Med-Uk. 2020 Dec;15(1):1-12 IHC ; Mouse. PubMed:33014123 [IF=2.86] Li, Wei, et al. "Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo." International journal of molecular sciences 12.1 (2011): 668-681. WB ; Mouse. PubMed:21340007 [IF=2.81] Liu et al. Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression. (2014) PLoS.On. 9:e98560 WB ; Human. PubMed:24901713 [IF=2.72] Weifeng Li. et al. Schisandrin improves lipopolysaccharide-induced acute lung injury by inhibiting the inflammatory response in vivo and in?vitro. 2022 Mar 21 WB ; Mouse,Human. PubMed:35313003 [IF=2.65] Shengqi Niu. et al. Jatrorrhizine Alleviates DSS-Induced Ulcerative Colitis by Regulating the Intestinal Barrier Function and Inhibiting TLR4/MyD88/NF-κB Signaling Pathway.. EVID-BASED COMPL ALT. 2022 Sep;2022:3498310-3498310 WB ; Mouse. PubMed:36193153 [IF=2.535] Lei J et al. LncRNA SNHG1 Alleviates IL-1β-induced Osteoarthritis by Inhibiting miR-16-5p-mediated p38 MAPK and NF-κB Signaling Pathways. Biosci Rep. 2019 Aug 5. pii: BSR20191523. WB ; Human. PubMed:31383786 [IF=2.42] Li, Weifeng, et al. "Protective effect of sanguinarine on LPS-induced endotoxic shock in mice and its effect on LPS-induced COX-2 expression and COX-2 associated PGE< sub> 2 release from peritoneal macrophages." International Immunopharmacology (2014). IHC-P ; Mouse. PubMed:25063710 [IF=2.408] Jingru Qin. et al. In-silico analysis identifies the anti-liver injury targets of diammonium glycyrrhizinate: validated in perfluorooctanoic acid-lesioned mouse model. 2022 Mar 31 IHC ; Mouse. PubMed:35362201
研究領域	腫瘤心血管免疫學信號轉導合成與降解新陳代謝
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human,Mouse
產品應用	WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理論分子量	65 kDa
檢測分子量
細胞定位	細胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Cyclooxygenase 2: 501-604/604
亞型	IgG
純化方法	affinity purified by Protein A
緩沖液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
產品介紹	Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009] Function: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Subunit: Homodimer. Subcellular Location: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Post-translational modifications: S-nitrosylation by NOS2 (iNOS) activates enzme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-561. Similarity: Belongs to the prostaglandin G/H synthase family. Contains 1 EGF-like domain. SWISS: P35354 Gene ID: 5743 Database links: Entrez Gene: 5743 Human Entrez Gene: 19225 Mouse Entrez Gene: 29527 Rat Omim: 600262 Human SwissProt: P35354 Human SwissProt: Q05769 Mouse SwissProt: P35355 Rat Unigene: 196384 Human Unigene: 292547 Mouse Unigene: 44369 Rat 合成與降解（Synthesis and Degradation） COX-2 前列腺素氧化環(huán)化酶-2是前列腺素合成的關鍵酶之一，為誘導性酶，他參與細胞對生長因子、腫瘤促進因子和細胞因子的反應，這些因子均能誘導COX2表達，它也參與前列腺素的合成。 COX2在80-90％的人結腸腺癌中表達顯著增高，而COX1表達卻不變。
產品圖片	RAW264.7 (M) cells were treated with or without LPS+BFA (100 ng/mL) for 6 h, 25 μg total protein per lane of cell lysates (see on figure) probed with Cyclooxygenase 2 polyclonal antibody, unconjugated (bs-0732R) at 1:1000 dilution and 4°C overnight incuba 25 ug total protein per lane of various lysates (see on figure) probed with Cyclooxygenase 2 polyclonal antibody, unconjugated (bs-0732R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 Paraformaldehyde-fixed, paraffin embedded Human Pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Cyclooxygenase 2 Polyclonal Antibody, Unconjugated (bs-0732R) at 1:200 overnight at 4°C, followed Paraformaldehyde-fixed, paraffin embedded Human Heart; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Cyclooxygenase 2 Polyclonal Antibody, Unconjugated (bs-0732R) at 1:200 overnight at 4°C, followed by Paraformaldehyde-fixed, paraffin embedded Human Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Cyclooxygenase 2 Polyclonal Antibody, Unconjugated (bs-0732R) at 1:200 overnight at 4°C, followed by Paraformaldehyde-fixed, paraffin embedded Human Colon; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Cyclooxygenase 2 Polyclonal Antibody, Unconjugated (bs-0732R) at 1:200 overnight at 4°C, followed by Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Cyclooxygenase 2 Polyclonal Antibody, Unconjugated (bs-0732R) at 1:200 overnight at 4°C, followed by Paraformaldehyde-fixed, paraffin embedded Human Esophagus Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Cyclooxygenase 2 Polyclonal Antibody, Unconjugated (bs-0732R) at 1:200 overnight at 4°C, f Paraformaldehyde-fixed, paraffin embedded Human Breast Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Cyclooxygenase 2 Polyclonal Antibody, Unconjugated (bs-0732R) at 1:200 overnight at 4°C, foll Paraformaldehyde-fixed, paraffin embedded Human Colon Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Cyclooxygenase 2 Polyclonal Antibody, Unconjugated (bs-0732R) at 1:200 overnight at 4°C, follo Paraformaldehyde-fixed, paraffin embedded Human Lung Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Cyclooxygenase 2 Polyclonal Antibody, Unconjugated (bs-0732R) at 1:200 overnight at 4°C, follow Paraformaldehyde-fixed, paraffin embedded Mouse Colon; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Cyclooxygenase 2 Polyclonal Antibody, Unconjugated (bs-0732R) at 1:200 overnight at 4°C, followed by Paraformaldehyde-fixed, paraffin embedded Human Liver Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Cyclooxygenase 2 Polyclonal Antibody, Unconjugated (bs-0732R) at 1:200 overnight at 4°C, follo Paraformaldehyde-fixed, paraffin embedded Mouse Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with Cyclooxygenase 2 Polyclonal Antibody, Unconjugated (bs-0732R) at 1:200 overnight at 4°C, followed by

	免疫組化常用試劑
	免疫印跡常用試劑
	各種標記二抗

	1、抗體溶解方法
	2、抗體修復方式
	3、常用試劑的配制
	4、免疫組化操作步驟
	5、免疫組化問題解答
	6、Western Blotting 操作步驟
	7、Western Blotting 問題解答
	8、關于肽鏈的設計
	9、多肽的溶解與保存
	10、酶標抗體效價測定程序

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